Beyond sales tax registration, Massachusetts businesses should consider: - Employer Withholding Tax Registration: For businesses with employees, registering for state income tax withholding. - Unemployment Insurance Registration: Registering with the Massachusetts Department of Unemployment Assistance. - Business Entity Registration: Registering the business structure with the Massachusetts Secretary of the Commonwealth. - Local Business Licenses and Permits: Acquiring necessary licenses based on business type and location. - Occupational Licenses: Obtaining specific licenses for regulated professions like healthcare or construction. - Corporation Excise Tax Registration: If operating as a corporation. - Property Tax Registration: Complying with local property tax requirements. These registrations ensure businesses comply with state and local regulations, avoid penalties, and operate legally.