Remote sellers can manage Massachusetts' economic nexus by closely monitoring their sales and transaction volumes within the state to determine if they meet the $100,000 sales or 200 transactions threshold. Implementing automated sales tracking and tax calculation systems ensures accurate compliance once thresholds are exceeded. Proactively registering for a sales tax permit through MassTaxConnect and integrating sales tax software streamline the collection and remittance process. Additionally, staying informed about legislative changes and consulting with tax professionals can help remote sellers navigate compliance efficiently, minimizing the risk of penalties and ensuring accurate tax reporting.